DYRK1A — Dual specificity tyrosine phosphorylation regulated kinase 1A
DYRK1A belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DYRK1A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | MAPK Kinase Signaling TCR Signaling | ARIH1, B4GALT1, BRAF, CDK16, CHD1, GNA13, KDM2A, MAP3K2 +8 more | |
| Lymphatic endothelial | Chromatin Remodeling DNA/chromatin regulation | HERC1, KDM6A, KMT2C, MBNL1, MED13L, MRTFA, NCOA1, PDE8A +2 more | View in SCUBA |
| Macrophages | Ubiquitin Proteasome Regulation Housekeeping | ARIH1, BTAF1, CLASP2, DENND4A, FBXO11, FBXW7, GATAD2B, LMBR1 +8 more | View in SCUBA |
| Mucosal-associated invariant T cell | SWI/SNF Chromatin Remodeling DNA/chromatin regulation | ABTB3, AOAH, ARID1B, ARID2, ATP8A1, ATXN1, BRAF, CCSER2 +13 more |
About the gene
| Synonyms | DYRK, DYRK1, MNBH |
|---|---|
| Chromosome | 21: 37365573-37526358 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase |
| Biological process | Host-virus interaction, Transcription, Transcription regulation |
Function
Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Plays an important role in double-strand breaks (DSBs) repair following DNA damage. Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR). Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Has pro- survival function and negatively regulates the apoptotic process (By similarity). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1 (By similarity). This in turn inhibits p53/TP53 activity and apoptosis (By similarity). Phosphorylates SEPTIN4, SEPTIN5 and SF3B1 at 'Thr-434' (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.