Ubiquitin Proteasome Regulation
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 17 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes include FBXO11, FBXW7 (F-box ubiquitin E3 ligases), ARIH1 (RBR E3 ubiquitin ligase), SENP5 (SUMO-specific protease), and BTAF1/GATAD2B (chromatin remodeling). CLASP2 adds a cytoskeletal component. The dominant theme across the highest-PageRank genes is ubiquitin-mediated protein degradation and SUMO regulation, with secondary chromatin remodeling. All genes show weak membership and uniform expression, indicating a loosely coupled regulatory module. Neighbor modules (M20, M116) also feature ubiquitin components, supporting a shared proteostasis neighborhood.
Genes
ARIH1, BTAF1, CLASP2, DENND4A, DYRK1A, FBXO11, FBXW7, GATAD2B, LMBR1, RALGAPA1, RERE, SCAF8, SENP5, TEC, TRAK1, UVRAG, ZSWIM6
Most correlated modules
- Golgi Vesicle Trafficking · correlation 0.98
- Rho GTPase Signaling · correlation 0.98
- Rho GTPase Signaling · correlation 0.98
- Chromatin Epigenetic Regulation · correlation 0.97
- Transcriptional Regulation · correlation 0.97
- MAPK Stress Kinase · correlation 0.97
- Endosomal Rab Trafficking · correlation 0.97
- Transcriptional Kinase Regulation · correlation 0.96
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.