TSPAN1 — Tetraspanin 1
TSPAN1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TSPAN1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Epithelial junction adhesion Migration & adhesion | ADGRG6, CEACAM6, CTNNB1, DSG2, KTN1, NCOA7, SAMD9L, SH3GLB1 +2 more | View in SCUBA |
About the gene
| Synonyms | NET-1, TSPAN-1 |
|---|---|
| Chromosome | 1: 46175073-46185962 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
Function
Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Regulates neuronal differentiation in response to NGF by facilitating NGF-mediated activation of NTRK1/TRKA receptor tyrosine kinase and subsequent downstream signaling pathways (By similarity). Plays a role in the inhibition of TNFalpha-induced apoptosis. Mechanistically, inhibits the NF-kappa-B signaling pathway by blocking phosphorylation of CHUK. Also promotes the stability of the thiamine transporter 1/SLC19A2 in intestinal epithelial cells leading to an increase of thiamine uptake process.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.