SH3GLB1 — SH3 domain containing GRB2 like, endophilin B1
SH3GLB1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SH3GLB1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cell cycle regulators DNA/chromatin regulation | CCDC28A, CCNDBP1, CFAP20, EAPP, IFNAR2, LAPTM4A, RBBP4 | View in SCUBA |
| CD8⁺ T cells | Autophagy Metabolic Stress Stress | CREM, CTSC, DNAJB6, DOK2, EFHD2, GNG2, ICOS, MAP1LC3B +2 more | View in SCUBA |
| Endothelial | Actin Cytoskeletal Remodeling Cytoskeletal | ACTR2, ANKRD11, ARPC4, CAP1, EIF4G1, FYTTD1, G3BP1, GSPT1 +8 more | View in SCUBA |
| Enterocytes | Epithelial junction adhesion Migration & adhesion | ADGRG6, CEACAM6, CTNNB1, DSG2, KTN1, NCOA7, SAMD9L, TOP1 +2 more | View in SCUBA |
| Innate lymphoid cells | Mitochondrial Translation Mitochondrial & OxPhos | ABCF1, ARGLU1, ATG12, BAG1, C1orf35, CHCHD1, CHMP5, DNAJC7 +37 more | View in SCUBA |
| Macrophages | Phagocytic Endolysosomal Lysosomal & pahgocytosis | ABHD2, ACTN4, AP3S1, ARF6, ATP6V1B2, CD151, CERS2, CNIH1 +27 more | View in SCUBA |
| Neutrophils | Mature Neutrophil Identity Developmental | ALPL, CR1, CRISPLD2, IL4R, NIBAN1, PXN, ST3GAL4 |
About the gene
| Synonyms | Bif-1, CGI-61, KIAA0491, PPP1R70 |
|---|---|
| Chromosome | 1: 86704570-86748184 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted intracellular proteins, Transporters |
| Biological process | Apoptosis, Autophagy |
Function
May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells (By similarity). May recruit other proteins to membranes with high curvature. May promote membrane fusion. Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation. Isoform 1 acts proapoptotic in fibroblasts (By similarity). Involved in caspase- independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2. Isoform 2 acts antiapoptotic in neuronal cells; involved in maintenance of mitochondrial morphology and promotes neuronal viability (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.