PTGDR — Prostaglandin D2 receptor
PTGDR belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PTGDR's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytotoxic effector Cytotoxicity | ADAM23, CTSW, EMP3, FKBP2, IFITM2, IGFBP3, KLRG1, LYAR +11 more | View in SCUBA |
| Gamma-delta T cells | Effector Cytokine Secretion Inflammation | APBA2, ASPH, CCL3, CCL4, CMC1, CYRIA, DTHD1, DTNBP1 +25 more | |
| Goblet cells | Anti-inflammatory Lipid Signaling Housekeeping | AQP1, CDCA7, FBL, IMPDH2, PRDX5, RARRES2, UGT2A3 | View in SCUBA |
| Innate lymphoid cells | JAK-STAT Cytokine Signaling Inflammation | AASDHPPT, ARHGAP9, CHURC1, CIDEB, CSK, DCAF7, DENND2D, EDEM2 +23 more | View in SCUBA |
| Mucosal-associated invariant T cell | Chemokine Receptor Migration migration & adhesion | CCR1, CCR2, CCR5, CD47, FAM78A, KRIT1, LUC7L3, MTG1 +6 more | |
| Natural Killer cells | NK Lymphocyte Survival Immune regulation | DENND2D, FGR, GIMAP1, GIMAP4, GIMAP7, IL16, SLAMF6, TRAF3IP3 | View in SCUBA |
About the gene
| Synonyms | DP, DP1, PTGDR1 |
|---|---|
| Chromosome | 14: 52267698-52276724 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, FDA approved drug targets, G-protein coupled receptors, Human disease related genes, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
| Biological process | Mast cell degranulation |
Function
Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity). Involved in PLA2G3- dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.