Anti-inflammatory Lipid Signaling
Gene co-expression module in Goblet cells
| Category | Housekeeping |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
RARRES2 (chemerin/RARRES2) is an anti-inflammatory adipokine and chemoattractant, highly expressed in normal colonic epithelium and down in IBD. PTGDR (prostaglandin D2 receptor) mediates anti-inflammatory prostaglandin signaling. AQP1 is a water channel expressed in colonocytes. UGT2A3 is a UDP-glucuronosyltransferase involved in detoxification/metabolism. FBL (fibrillarin) methylates rRNA. IMPDH2 is rate-limiting for de novo purine synthesis. PRDX5 is an antioxidant peroxiredoxin. CDCA7 is involved in cell cycle/DNA methylation. The most dramatically inflammation-suppressed module in the batch (delta_inflammation ~-1.4). RARRES2 and PTGDR define an anti-inflammatory lipid/chemokine signaling theme. The peroxiredoxin and UDP-glucuronosyltransferase suggest additional metabolic/detox functions of healthy colonocytes.
Genes
AQP1, CDCA7, FBL, IMPDH2, PRDX5, PTGDR, RARRES2, UGT2A3
Most correlated modules
- Mitochondrial Metabolism · correlation 0.76
- Mature Colonocyte Function · correlation 0.76
- Colonocyte Differentiation Program · correlation 0.71
- Mitochondrial Homeostasis · correlation 0.70
- Colonocyte Metabolic Defense · correlation 0.70
- mRNA Translation Initiation · correlation 0.67
- Mitochondrial OxPhos · correlation 0.63
- Oxidative Phosphorylation · correlation 0.51
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.