VWF — Von Willebrand factor
VWF belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
VWF's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Quiescence Identity Endothelial cell development | CCDC69, CLIC2, CLSTN3, CPD, EPB41L4A, FOXF1, FZD4, IGFBP7 +7 more | View in SCUBA |
| Pericytes | Basement Membrane Maintenance ECM production | CALCRL, DYSF, EXOC3L1, FAM167B, GRB10, HSPG2, PPM1F, RAPGEF4 +1 more | View in SCUBA |
About the gene
| Synonyms | F8VWF |
|---|---|
| Chromosome | 12: 5948877-6124770 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted secreted proteins |
| Biological process | Blood coagulation, Cell adhesion, Hemostasis |
Function
Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.