WIPF2 — WAS/WASL interacting protein family member 2
WIPF2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
WIPF2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | NF-kB signaling BCR/AP1/NFKb pathway | ARIH1, BACH1, BRAF, HERPUD1, MTMR6, RAB21, RASGEF1B, REL +5 more | View in SCUBA |
About the gene
| Synonyms | WICH, WIRE |
|---|---|
| Chromosome | 17: 40219304-40284136 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Actin-binding |
Function
Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.