MTMR6 — Myotubularin related protein 6
MTMR6 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MTMR6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | NF-kB signaling BCR/AP1/NFKb pathway | ARIH1, BACH1, BRAF, HERPUD1, RAB21, RASGEF1B, REL, RNMT +5 more | View in SCUBA |
| CD4⁺ T cells | Transcription/RNA processing RNA processing | ANKRD17, BDP1, CCDC97, CDK13, CHIC2, CLK4, CNOT6L, CRNKL1 +29 more | View in SCUBA |
| Macrophages | ER-Golgi Trafficking Vesicular traficking | ADD1, AFTPH, AZIN1, COPA, DYNC1H1, HNRNPC, JOSD1, LCP2 +23 more | View in SCUBA |
About the gene
| Chromosome | 13: 25246222-25287510 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase |
| Biological process | Endocytosis, Lipid metabolism |
Function
Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine. Negatively regulates ER-Golgi protein transport (By similarity). Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+) T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate. Negatively regulates proliferation of reactivated CD4(+) T-cells. In complex with MTMR9, negatively regulates DNA damage-induced apoptosis. The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.