REL — REL proto-oncogene, NF-kB subunit

REL belongs to a gene co-expression module in 12 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

REL's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	NF-kB signaling BCR/AP1/NFKb pathway	ARIH1, BACH1, BRAF, HERPUD1, MTMR6, RAB21, RASGEF1B, RNMT +5 more	View in SCUBA
CD4⁺ T cells	NF-kB activation TCR/AP1/NFKb pathway	ABCF1, BCL2A1, BUD23, BZW2, CALR, CEBPZ, DDX21, DENND4A +21 more	View in SCUBA
Endothelial	Endothelial Chemokine Response Chemotaxis	BMP2, CCL2, CEBPB, CEBPD, CNKSR3, CXCL1, CXCL2, CXCL3 +14 more	View in SCUBA
Fibroblasts	NF-κB Epigenetic Reprogramming Inflammatory	BCL3, BTG2, CDKN1A, CSRNP1, DUSP5, EGR2, KDM6B, KLF10 +3 more	View in SCUBA
Gamma-delta T cells	Chromatin Epigenetic Regulation DNA/chromatin regulation	ADNP2, ARID4B, CEBPZ, ELL2, ENSG00000285976, ETF1, HIPK1, JMJD1C +17 more
Goblet cells	NF-kB Inflammatory Signaling chromatin regulation & transcription	CD69, CXCR4, DDX21, DUSP2, FOSL2, IRF1, NFKB2, RGCC +5 more	View in SCUBA
Innate lymphoid cells	NF-κB Inflammatory Activation Inflammation	AHI1, CD83, FAM107B, FKBP2, GADD45A, HES4, KDM6B, MRPS36 +7 more	View in SCUBA
Macrophages	NF-κB Activation Inflammatory	BCL3, BLOC1S6, CD83, CFLAR, CHMP1B, CNOT2, CSRNP1, CYLD +33 more	View in SCUBA
Monocytes	NF-κB Signaling Inflammatory	BIRC3, ERN1, G0S2, ICAM1, IER3, IRAK2, NFKB1, PDE4B +4 more	View in SCUBA
Mucosal-associated invariant T cell	NF-κB Activation Inflammation	DUSP5, DUSP8, ELL2, GABARAPL1, IRF2BP2, MAFF, NAMPT, NFKB1 +8 more
Natural Killer cells	NF-κB Activation Inflammation	ARL5B, BIRC3, CD83, KDM6B, NFKBID, NR4A1, NR4A3, RASGEF1B	View in SCUBA
Neutrophils	NF-κB Inflammatory Transcription Inflammatory	BID, C9orf72, DENND5A, ELL2, ETF1, N4BP1, NFE2L2, NFKB1 +10 more

About the gene

Synonyms	c-Rel, HIVEN86A, I-Rel
Chromosome	2: 60881491-60931612
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, RAS pathway related proteins, Transcription factors
Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation

Function

Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post- translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I- kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65- c-Rel is a transcriptional activator

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.