RASGEF1B — RasGEF domain family member 1B

RASGEF1B belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

RASGEF1B's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	NF-kB signaling BCR/AP1/NFKb pathway	ARIH1, BACH1, BRAF, HERPUD1, MTMR6, RAB21, REL, RNMT +5 more	View in SCUBA
CD4⁺ T cells	NF-kB Feedback Response TCR/AP1/NFKb pathway	ADGRE5, ARL5B, ATF3, CSRNP1, NFKBIZ, PPP1R15B, TIPARP, TNFAIP3 +2 more	View in SCUBA
Enterocytes	Mature enterocyte transport Absorption	ABCG8, ANO6, ANXA13, KAZN, PIK3C2G, SLC16A10, TCEA3, TLN2 +1 more	View in SCUBA
Gamma-delta T cells	Stress Negative Feedback Immune regulation	ANKRD12, AZIN1, CCDC186, CDKN1A, CYLD, DENND4A, DNAJB6, DUSP10 +7 more
Hematopoietic progenitor cells	Glucocorticoid Response Inflammatory	ARL4C, CYTH1, EMP1, ETS1, FOS, KLF6, LRRFIP1, PDE4B +4 more
Innate lymphoid cells	NF-κB Inflammatory Activation Inflammation	AHI1, CD83, FAM107B, FKBP2, GADD45A, HES4, KDM6B, MRPS36 +7 more	View in SCUBA
Macrophages	NF-κB Activation Inflammatory	BCL3, BLOC1S6, CD83, CFLAR, CHMP1B, CNOT2, CSRNP1, CYLD +33 more	View in SCUBA
Monocytes	Inflammatory Stress Response Stress	ARL5B, ATF3, CCRL2, CD83, DUSP10, IL1B, NFE2L2, SGK1 +2 more	View in SCUBA
Mucosal-associated invariant T cell	NF-κB Effector Activation Inflammation	ADGRE5, BCL2A1, CCL20, CCL3, CCL3L3, CCL4, CCL4L2, DUSP10 +10 more
Natural Killer cells	NF-κB Activation Inflammation	ARL5B, BIRC3, CD83, KDM6B, NFKBID, NR4A1, NR4A3, REL	View in SCUBA

About the gene

Synonyms	FLJ31695, GPIG4
Chromosome	4: 81426393-82044244
Predicted location	Intracellular, Membrane
Essential gene	No
Protein class	Predicted intracellular proteins, Predicted membrane proteins
Molecular function	Guanine-nucleotide releasing factor

Function

Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, it doesn't seems to activate other Ras family proteins (in vitro)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.