NF-kB signaling
Gene co-expression module in CD19⁺ B cells
| Category | BCR/AP1/NFKb pathway |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes BACH1, REL, and ZBTB1 are transcription factors; REL is a core NF-kB family member, and the module includes HERPUD1 (ER stress/NFKB target), RASGEF1B (an NFKB-inducible immediate-early gene), and several ubiquitin pathway members (ARIH1, UBE2B). The combination of REL with immediate-early/NFKB-responsive genes points to NFKB pathway signaling. Coherence is core with uniform expression suggesting a B-cell-intrinsic activation program rather than contamination. Neighboring modules (M9, M63) also carry NFKB/AP1-related members supporting this.
Genes
ARIH1, BACH1, BRAF, HERPUD1, MTMR6, RAB21, RASGEF1B, REL, RNMT, RYBP, UBE2B, WIPF2, YWHAZ, ZBTB1
Most correlated modules
- Immediate early response · correlation 0.88
- Chromatin Modification · correlation 0.86
- NF-kB activation/survival · correlation 0.84
- Integrated Stress Response · correlation 0.82
- Plasma cell secretory · correlation 0.78
- Activation/Migration · correlation 0.78
- mRNA Splicing · correlation 0.74
- B cell quiescence · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.