RAB21 — RAB21, member RAS oncogene family
RAB21 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RAB21's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | NF-kB signaling BCR/AP1/NFKb pathway | ARIH1, BACH1, BRAF, HERPUD1, MTMR6, RASGEF1B, REL, RNMT +5 more | View in SCUBA |
| CD4⁺ T cells | IL6-STAT3 Signaling Intercellular communication | ARID5A, ARL6IP1, AZIN1, CCDC66, CDC40, CEMIP2, CHD1, CSNK1D +13 more | View in SCUBA |
| Gamma-delta T cells | Chromatin Epigenetic Regulation DNA/chromatin regulation | ADNP2, ARID4B, CEBPZ, ELL2, ENSG00000285976, ETF1, HIPK1, JMJD1C +17 more | |
| Innate lymphoid cells | NF-κB Inflammatory Activation Inflammation | AHI1, CD83, FAM107B, FKBP2, GADD45A, HES4, KDM6B, MRPS36 +7 more | View in SCUBA |
| Macrophages | ER-Golgi Trafficking Vesicular traficking | ADD1, AFTPH, AZIN1, COPA, DYNC1H1, HNRNPC, JOSD1, LCP2 +23 more | View in SCUBA |
| Mucosal-associated invariant T cell | NF-κB Survival Signaling Immune regulation | BIRC2, CWC25, GATA3, IL4I1, KPNA2, OAT, OTULIN, PIM2 +4 more | |
| Smooth muscle cells | STAT3 transcriptional program Activation | DDX3X, FAM210B, HLA-E, HNRNPH1, ID4, ITPR1, NOLC1, STAT3 +2 more | View in SCUBA |
About the gene
| Synonyms | KIAA0118 |
|---|---|
| Chromosome | 12: 71754863-71800286 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase |
| Biological process | Protein transport, Transport |
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB21 is involved in membrane trafficking control. During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis. Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (By similarity). As a result, may regulate cell adhesion and migration (By similarity). Involved in neurite growth (By similarity). Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion. Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.