YEATS4 — YEATS domain containing 4
YEATS4 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
YEATS4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Replication Licensing Cell cycle | ASF1B, CDC6, CDCA5, CDT1, CENPK, CENPU, CLSPN, DNAJC9 +5 more | View in SCUBA |
| CD8⁺ T cells | Replication Licensing Cell cycle | ACYP1, DDB2, DSN1, GMNN, HIRIP3, ITGB3BP, LSM3, MAGOHB +8 more | View in SCUBA |
About the gene
| Synonyms | GAS41, NuBI-1, YAF9 |
|---|---|
| Chromosome | 12: 69359710-69390870 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | Chromatin regulator |
| Biological process | Growth regulation, Transcription, Transcription regulation |
Function
Chromatin reader component of the NuA4 histone acetyltransferase (HAT) complex, a complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. Specifically recognizes and binds acylated histone H3, with a preference for histone H3 diacetylated at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac) or histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac). Also able to recognize and bind crotonylated histone H3. May also recognize and bind histone H3 succinylated at 'Lys-122' (H3K122succ); additional evidences are however required to confirm this result in vivo. Plays a key role in histone variant H2AZ1/H2A.Z deposition into specific chromatin regions: recognizes and binds H3K14ac and H3K27ac on the promoters of actively transcribed genes and recruits NuA4-related complex to deposit H2AZ1/H2A.Z. H2AZ1/H2A.Z deposition is required for maintenance of embryonic stem cell (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.