ASF1B — Anti-silencing function 1B histone chaperone
ASF1B belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ASF1B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Replication Licensing Cell cycle | CDC6, CDCA5, CDT1, CENPK, CENPU, CLSPN, DNAJC9, FAM111B +5 more | View in SCUBA |
| CD8⁺ T cells | Mitotic Spindle Cell cycle | CENPN, DDX39A, DTYMK, GGH, HMGB2, HMGN2, LMNB1, STMN1 +3 more | View in SCUBA |
| Gamma-delta T cells | Mitosis Execution Cell cycle | BUB1, CDCA8, CENPE, CENPF, CKS1B, EZH2, MAD2L1, MKI67 +12 more | |
| Goblet cells | S-phase DNA Replication Cell cycle | BRCA1, CDC6, CENPU, DHFR, FEN1, MYBL2, PCLAF, TK1 +1 more | View in SCUBA |
| Hematopoietic progenitor cells | Late S-phase G2 Entry Cell cycle | CDC45, CDCA5, CENPM, DIAPH3, MND1, MYBL2, PKMYT1, RAD51AP1 +1 more |
About the gene
| Synonyms | FLJ10604 |
|---|---|
| Chromosome | 19: 14119512-14136613 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Chaperone, Chromatin regulator, Developmental protein |
| Biological process | Differentiation, Spermatogenesis, Transcription, Transcription regulation |
Function
Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' (H3K9me1) and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol. Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA. Required for gonad development.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.