ZFP91 — ZFP91 zinc finger protein, atypical E3 ubiquitin ligase
ZFP91 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ZFP91's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | DNA Damage Ubiquitin DNA/chromatin regulation | ACBD3, CDADC1, CTPS1, CWC25, FNIP1, ING3, KLHL18, RALGAPA1 +7 more | |
| Macrophages | Macrophage Lipid Sensing Lipid metabolism | ARL4A, ARL4C, BIRC2, CES2, DDX21, DDX24, DDX27, GPR183 +12 more | View in SCUBA |
About the gene
| Synonyms | PZF, ZNF757 |
|---|---|
| Chromosome | 11: 58579063-58621550 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins, Transcription factors |
| Molecular function | Transferase |
| Biological process | Ubl conjugation pathway |
Function
Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'- linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF- kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.