Antiviral Restriction
Gene co-expression module in CD19⁺ B cells
| Category | Anti-viral |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 4 of 10 genes have a known function matching the annotation |
Why this annotation
Top hubs ZC3HAV1 (ZAP, antiviral restriction), SP140L, SP100 (nuclear body ISGs/restriction factors) define an interferon-stimulated antiviral program. STAT3 and TGFB1 are signaling components. ZC3HAV1, SP100, SP140L are all interferon-induced viral restriction factors. Core coherence, CD-inflammation associated. Clearly an antiviral/interferon module.
Genes
FCRL1, GLS, PPM1K, SP100, SP140L, STAT3, TGFB1, TSC22D2, WSB1, ZC3HAV1
Most correlated modules
- Chromatin Regulation · correlation 0.84
- mRNA Splicing · correlation 0.80
- B-cell signaling regulators · correlation 0.77
- Chromatin Modification · correlation 0.74
- Interferon Response · correlation 0.73
- ATF4 Stress Response · correlation 0.72
- TGF-beta/differentiation · correlation 0.69
- MHC-II antigen presentation · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.