Glycolysis OxPhos
Gene co-expression module in CD19⁺ B cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes are glycolytic enzymes (ENO1, with downstream MDH2 TCA) and mitochondrial energy metabolism: VDAC1 (outer membrane porin), ATP5F1B (ATP synthase), NDUFB2 (complex I), MDH2 (TCA). PARK7 (DJ-1, redox/glycolysis), PPA1, PSMA7/PSMB1 proteasome. Overall an energy metabolism module spanning glycolysis and OxPhos.
Genes
ATP5F1B, ENO1, MDH2, NDUFB2, PARK7, PPA1, PRELID1, PSMA7, PSMB1, VDAC1
Most correlated modules
- Oxidative Phosphorylation · correlation 0.98
- Spliceosome snRNP · correlation 0.97
- Mitochondrial Translation · correlation 0.97
- Nucleotide Metabolism Biosynthesis · correlation 0.97
- Oxidative Phosphorylation · correlation 0.97
- Glycolysis Biosynthesis · correlation 0.97
- Oxidative Phosphorylation · correlation 0.95
- Chaperonin Protein Folding · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.