Nucleotide Metabolism Biosynthesis
Gene co-expression module in CD19⁺ B cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 22 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 22 genes have a known function matching the annotation |
Why this annotation
A mixed biosynthetic/metabolic module. Hub genes include nucleotide/one-carbon metabolism (NME1, DCTPP1, ATIC, SRM polyamine), translation factors (EIF5A, EEF1E1), arginine methyltransferase PRMT1, rRNA processing (NHP2), chaperonin CCT7, mitochondrial ribosomal proteins (MRPL4, MRPL12, MRPS12), mito import (TIMM13), OxPhos (ATP5MC1, NDUFAF8) and C1QBP/MIF. Together this is a proliferation-linked anabolic metabolism program (nucleotide synthesis, translation, mitochondrial biogenesis). Core coherence, uniform expression, inflammation-up. Consistent with the proliferative biosynthetic theme shared by M15 and M2.
Genes
ATIC, ATP5MC1, C1QBP, CCT7, DCTPP1, EBNA1BP2, EEF1E1, EIF5A, GADD45GIP1, ISOC2, MIF, MRPL12, MRPL4, MRPS12, NDUFAF8, NHP2, NME1, POLR2E, PRMT1, SRM, SSBP1, TIMM13
Most correlated modules
- Mitochondrial Translation · correlation 0.98
- Glycolysis Biosynthesis · correlation 0.97
- Glycolysis OxPhos · correlation 0.97
- Chaperonin Protein Folding · correlation 0.95
- Spliceosome snRNP · correlation 0.94
- Oxidative Phosphorylation · correlation 0.93
- Proteasome Complex · correlation 0.93
- Oxidative Phosphorylation · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.