Chaperonin Protein Folding
Gene co-expression module in CD19⁺ B cells
| Category | Protein processing & ER |
|---|---|
| Genes | 14 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes are dominated by the CCT/TRiC chaperonin complex (CCT2, CCT3, CCT4, CCT5, CCT6A) plus prefoldin (PFDN2) and the co-chaperone NUDC, which fold cytoskeletal and many other proteins. RUVBL1, ILF2, BANF1, PSMC1, EIF2S1 and mitochondrial ribosomal proteins (MRPL14, MRPL15) indicate a high biosynthetic/protein-homeostasis program. Core coherence, uniform expression, upregulated with inflammation — consistent with a proliferative/anabolic chaperone program rather than a specific signaling pathway. The neighbors (M2, M8) share the same proteostasis/biogenesis theme.
Genes
BANF1, CCT2, CCT3, CCT4, CCT5, CCT6A, EIF2S1, ILF2, MRPL14, MRPL15, NUDC, PFDN2, PSMC1, RUVBL1
Most correlated modules
- Glycolysis Biosynthesis · correlation 0.96
- Proteasome Complex · correlation 0.96
- Spliceosome snRNP · correlation 0.96
- Mitochondrial Translation · correlation 0.95
- Glycolysis OxPhos · correlation 0.95
- Nucleotide Metabolism Biosynthesis · correlation 0.95
- RNA Processing · correlation 0.94
- Oxidative Phosphorylation · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.