SCUBA

NDUFB2 — NADH:ubiquinone oxidoreductase subunit B2

NDUFB2 belongs to a gene co-expression module in 13 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

NDUFB2's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsGlycolysis OxPhos
Mitochondrial & OxPhos
ATP5F1B, ENO1, MDH2, PARK7, PPA1, PRELID1, PSMA7, PSMB1 +1 moreView in SCUBA
CD4⁺ T cellsOxPhos & redox
Mitochondrial & OxPhos
ATOX1, CHCHD2, HNRNPR, KIF5B, MRPS21, NDUFAB1, NDUFB1, POMP +5 moreView in SCUBA
CD8⁺ T cellsMitochondrial OxPhos
Mitochondrial & OxPhos
COX6B1, COX6C, COX7A2, COX7B, DBI, ELOB, LSM7, POMP +5 moreView in SCUBA
EndothelialMitochondrial OxPhos
Mitochondrial & OxPhos
ARPC1B, ATP5MF, AURKAIP1, NDUFS6, PARVB, PFN1, POLR2E, SERF2 +3 moreView in SCUBA
EnterocytesElectron Transport Chain
Mitochondrial & OxPhos
ATP5MG, ATP5MJ, ATP5PD, ATP5PO, COX5B, COX6B1, COX7B, COX7C +6 moreView in SCUBA
Gamma-delta T cellsCytotoxic Effector Actin
cytotoxicity
ARPC2, ARPC5, ATOX1, BRK1, CFL1, CLIC1, CORO1A, DBI +14 more
Glial cellsGlial Neuroprotective Response
Neroprotection
ANXA4, CYB5A, DPYSL3, DRAP1, FADS2, IGFBP4, MDK, NBDY +4 moreView in SCUBA
Goblet cellsMitochondrial OxPhos
Mitochondrial & OxPhos
ATP5MC1, ATP5MC3, ATP5PF, DBI, MTCH2, NDUFA12, TPI1View in SCUBA
Innate lymphoid cellsActin Cytoskeleton Remodeling
Cytoskeleton & motility
APRT, ARPC2, ARPC3, ATP5F1E, ATP6V0E1, C11orf58, CFL1, CHCHD2 +17 moreView in SCUBA
Lymphatic endothelialMitochondrial OxPhos Complex
Mitochondrial & OxPhos
ANAPC11, AP2M1, BRK1, LSM3, MRPL51, MRPS21, NDUFA12, NDUFAB1 +6 moreView in SCUBA
MacrophagesOxidative Phosphorylation
Mitochondrial & OxPhos
ATP5F1C, ATP5MC3, ATP5PD, ATP5PO, COX5B, COX6C, LAMTOR2, MICOS10 +7 moreView in SCUBA
Mucosal-associated invariant T cellER Glycosylation & Ubiquitin
Protein processing & ER
AIP, ALDOA, ATP5MG, COX6A1, COX6B1, ELOB, FIS1, GAPDH +9 more
Smooth muscle cellsOxPhos & proteasome
Mitochondrial & OxPhos
CD151, CHCHD2, COX5B, EID1, NDUFA11, NDUFB9, NEDD8, PARK7 +8 moreView in SCUBA

About the gene

SynonymsAGGG, CI-AGGG
Chromosome7: 140690777-140722790
Predicted locationIntracellular, Membrane
Essential geneNo
Protein classMetabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Biological processElectron transport, Respiratory chain, Transport

Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.