Mitochondrial Translation
Gene co-expression module in CD19⁺ B cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes are mitochondrial ribosomal proteins (MRPS34, MRPL36, MRPL20), mitochondrial import/assembly factors (TIMM10, BOLA3, SLIRP) and proteasome subunits (PSMA3, PSMB5) plus POLR2I. This is a mitochondrial biogenesis/translation and protein turnover module reflecting high metabolic activity in proliferating B cells. Core coherence, uniform expression, inflammation-associated. Shares the biosynthetic/proteostasis theme with neighbors M15 and M8.
Genes
BOLA3, MRPL20, MRPL36, MRPS34, PDCD5, POLR2I, PSMA3, PSMB5, RPL26L1, SLIRP, TIMM10
Most correlated modules
- Nucleotide Metabolism Biosynthesis · correlation 0.98
- Glycolysis Biosynthesis · correlation 0.98
- Glycolysis OxPhos · correlation 0.97
- Oxidative Phosphorylation · correlation 0.96
- Proteasome Complex · correlation 0.95
- Spliceosome snRNP · correlation 0.95
- Chaperonin Protein Folding · correlation 0.95
- RNA Processing · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.