MDH2 — Malate dehydrogenase 2
MDH2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MDH2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Glycolysis OxPhos Mitochondrial & OxPhos | ATP5F1B, ENO1, NDUFB2, PARK7, PPA1, PRELID1, PSMA7, PSMB1 +1 more | View in SCUBA |
| CD4⁺ T cells | Oxidative Phosphorylation Mitochondrial & OxPhos | AP2S1, ATP5F1C, ATP5PF, COPS9, COX6B1, EID1, FAM89B, FDPS +19 more | View in SCUBA |
| Fibroblasts | Mitochondrial Energy Metabolism Mitochondrial & OxPhos | ATP5MC3, COX5A, COX7B, GAPDH, LDHB, NDUFA6, SLC25A3, TOMM20 | View in SCUBA |
| Innate lymphoid cells | Proteasome & TCA Protein processing & ER | ACP1, ARPC5L, CAPZA1, CLTA, COPS9, HDAC1, NDUFA1, NUDT16L1 +5 more | View in SCUBA |
| Macrophages | Mitochondrial Biogenesis Mitochondrial & OxPhos | AIMP1, ATP5F1D, ATP5MC1, C1QBP, CCT2, CCT3, CCT7, CHCHD1 +38 more | View in SCUBA |
About the gene
| Chromosome | 7: 76048051-76067508 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Citric acid cycle related proteins, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
| Biological process | Tricarboxylic acid cycle |
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.