Oxidative Phosphorylation
Gene co-expression module in CD19⁺ B cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 15 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes are dominated by mitochondrial respiratory chain components: COX6B1, COX6C, COX6A1, COX7 (cytochrome c oxidase / Complex IV), NDUFA4, NDUFA11 (Complex I), UQCRH (Complex III), ATP5ME, ATP5F1D (ATP synthase). A few RNA processing genes (UBL5, TXNL4A, SF3B6) and ER (SEC61G) are peripheral. The module is clearly an oxidative phosphorylation/electron transport chain program. Uniform expression, core coherence. Neighbors M41, M97 share the same OxPhos signature, supporting this label.
Genes
ATP5F1D, ATP5ME, COX6A1, COX6B1, COX6C, DNAJC8, NDUFA11, NDUFA4, NEDD8, RTRAF, SEC61G, SF3B6, TXNL4A, UBL5, UQCRH
Most correlated modules
- Oxidative Phosphorylation · correlation 0.98
- Oxidative Phosphorylation · correlation 0.98
- Glycolysis OxPhos · correlation 0.97
- Spliceosome snRNP · correlation 0.96
- Oxidative Phosphorylation · correlation 0.95
- Proteasome Complex · correlation 0.94
- Mitochondrial Redox · correlation 0.93
- mRNA Splicing · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.