SAV1 — Salvador family WW domain containing protein 1
SAV1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SAV1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B cell identity B cell maturation | C12orf42, CD37, DRAM2, GNG7, ITM2B, PRICKLE1, RBMS1, TNFRSF13C | View in SCUBA |
| Endothelial | Endothelial Quiescence Endothelial cell development | CCRL2, CDC42EP3, CGAS, CHSY1, CYTH1, HES5, HIPK3, ID1 +7 more | View in SCUBA |
| Macrophages | NF-κB Inflammatory Activation Inflammatory | ADM, CCL2, CCL20, CCL7, CLEC4E, CXCL1, CXCL2, CXCL3 +19 more | View in SCUBA |
About the gene
| Synonyms | salvador, WW45, WWP4 |
|---|---|
| Chromosome | 14: 50632058-50668306 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell- cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.