B cell quiescence
Gene co-expression module in CD19⁺ B cells
| Category | BCR/AP1/NFKb pathway |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes CXCR4, ZFP36L2, BTG1, PNRC1, YPEL5, BTG1 are classic immediate-early / quiescence and trafficking genes. CXCR4 drives B cell homing; ZFP36L2 and BTG1 are anti-proliferative mRNA-destabilizing factors associated with B cell quiescence/circulating naive states. AREG and CD55 add an activation/regulatory flavor. This is a B cell quiescence/early-activation transcriptional program rather than an artifact, with core coherence.
Genes
AREG, BTG1, CD55, CXCR4, LY9, PNRC1, TUBA1A, YPEL5, ZFP36L2
Most correlated modules
- AP-1 Immediate Early · correlation 0.90
- Hypoxia/metabolic stress · correlation 0.89
- Integrated Stress Response · correlation 0.86
- B cell identity · correlation 0.85
- Early Response Stress · correlation 0.84
- Plasma cell secretory · correlation 0.83
- Immediate early response · correlation 0.77
- Adhesion/Migration · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.