MHC-I Antigen Presentation
Gene co-expression module in CD19⁺ B cells
| Category | Anti-viral |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
Dominated by MHC class I genes HLA-A/B/C/E/F and B2M, plus CD48, BANK1. This is a clear antigen presentation / MHC-I module, often interferon-inducible. High expression (mean 1.85, 72% positive). BANK1 and CD48 are B-cell markers confirming intrinsic expression. The coordinated HLA/B2M signature reflects antigen presentation, an interferon-associated antiviral-type program.
Genes
B2M, BANK1, CD48, CYSLTR1, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, RNASET2
Most correlated modules
- Membrane adhesion remodeling · correlation 0.85
- Interferon Response · correlation 0.85
- Adhesion/Migration · correlation 0.79
- Chromatin Regulation · correlation 0.78
- MHC-II antigen presentation · correlation 0.78
- Activation/Migration · correlation 0.72
- AP-1 Immediate Early · correlation 0.72
- B cell activation signaling · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.