Adhesion/Migration
Gene co-expression module in CD19⁺ B cells
| Category | migration & adhesion |
|---|---|
| Genes | 20 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include adhesion/migration molecules JAM3, ADAM28, SPOCK2, ARHGAP24, ARHGAP5, ADAMTS6 and GPCRs P2RY10. FCMR, FCRL-like B-cell receptors present. The combination of junctional adhesion (JAM3), ADAM/ADAMTS proteases, RhoGAPs (ARHGAP24/5) and chemoreceptor P2RY10 points to a cell migration & adhesion program. Strongest disease association (sig in both UC and CD, treatment-responsive).
Genes
ADAM28, ADAMTS6, ARHGAP24, ARHGAP5, CHPT1, CLMN, CMTR2, FCMR, JAM3, MAML2, MOB3B, NLRP1, ODF2L, P2RY10, RIC3, SARAF, SIDT1, SPOCK2, TGIF1, TXNIP
Most correlated modules
- Chromatin Regulation · correlation 0.84
- B cell identity · correlation 0.83
- Interferon Response · correlation 0.82
- MHC-I Antigen Presentation · correlation 0.79
- B cell quiescence · correlation 0.77
- B-cell Maturation · correlation 0.74
- AP-1 Immediate Early · correlation 0.70
- Hypoxia/metabolic stress · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.