Hypoxia/metabolic stress
Gene co-expression module in CD19⁺ B cells
| Category | Stress |
|---|---|
| Genes | 11 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes SLC2A3 (GLUT3, hypoxia/metabolic stress), ARL4A, ZNF331 (immediate-early zinc finger), PDE4B, ZNF703, VPS37B form a metabolic/stress-responsive activation program. SLC2A3 and PDE4B are hallmark hypoxia and inflammatory-activation markers in immune cells. delta_inflammation_CD significant, supporting an inflammation-linked activation/stress module.
Genes
ALG13, ARL4A, C9orf72, HIP1R, PDE4B, SC5D, SLC2A3, TENT5C, VPS37B, ZNF331, ZNF703
Most correlated modules
- Plasma cell secretory · correlation 0.92
- Immediate early response · correlation 0.89
- B cell quiescence · correlation 0.89
- Notch signaling · correlation 0.85
- B cell identity · correlation 0.72
- Integrated Stress Response · correlation 0.71
- Early Response Stress · correlation 0.71
- NF-kB signaling · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.