AP-1 Immediate Early
Gene co-expression module in CD19⁺ B cells
| Category | BCR/AP1/NFKb pathway |
|---|---|
| Genes | 16 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 15 of 16 genes have a known function matching the annotation |
Why this annotation
Classic immediate-early/AP-1 module: FOSB, JUN, FOS, JUNB, JUND, NR4A1, EGR-like, plus DUSP1, CD69, CD83, BTG2, NFKBID, KLF2. This is the canonical AP-1/NF-kB immediate early gene program, often reflecting BCR/activation signaling. Core coherence with these hubs is definitive.
Genes
BTG2, CD69, CD83, DUSP1, EIF1, FOS, FOSB, JUN, JUNB, JUND, KDM6B, KLF2, NFKBID, NR4A1, PPP1R15A, TSC22D3
Most correlated modules
- Early Response Stress · correlation 0.92
- B cell quiescence · correlation 0.90
- Immediate Early NFkB · correlation 0.88
- Integrated Stress Response · correlation 0.86
- B cell identity · correlation 0.74
- Immediate early response · correlation 0.72
- MHC-I Antigen Presentation · correlation 0.72
- Activation/Migration · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.