Chromatin Regulation
Gene co-expression module in CD19⁺ B cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 17 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes are predominantly chromatin remodelers and RNA-binding/regulatory factors: CHD2, CHD7, TNRC6B, KDM7A, L3MBTL3, BBX, ANKRD12, plus deubiquitinases (USP15) and kinase MAP3K1. IRF1 present at low rank. The dominant theme is chromatin/transcriptional and post-transcriptional regulation (TNRC6B = GW182 miRNA effector, CHD2/CHD7 chromatin remodeling, KDM7A demethylase). Core coherence, uniform. Best described as a DNA/chromatin regulation program.
Genes
AKAP9, ANKRD12, BBX, CHD2, CHD7, IRF1, KDM7A, L3MBTL3, MAP3K1, N4BP2L2, PCMTD1, RALGPS2, RNF19A, TNRC6B, USP15, UTRN, VPS13C
Most correlated modules
- Interferon Response · correlation 0.86
- Antiviral Restriction · correlation 0.84
- Adhesion/Migration · correlation 0.84
- Chromatin Modification · correlation 0.81
- B cell identity · correlation 0.78
- MHC-I Antigen Presentation · correlation 0.78
- B-cell signaling regulators · correlation 0.75
- B cell activation signaling · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.