Integrated Stress Response
Gene co-expression module in CD19⁺ B cells
| Category | Stress |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes SKIL, PMAIP1 (NOXA), IFRD1, MIDN, DDIT3 (CHOP) point to integrated stress response and ATF4-driven program. DDIT3, PMAIP1, AMD1, MKNK2, ATF-related stress signaling dominate. SKIL is a TGF-beta/SMAD repressor. The combination represents a stress/apoptosis-related transcriptional program. Neighbors include other ISR/heat shock modules (M81 ATF4, M47 HSP), supporting a stress interpretation. Elevated in CD inflammation.
Genes
AMD1, DDIT3, FAM133B, GOLGB1, IFRD1, MIDN, MKNK2, PHF1, PIM2, PMAIP1, SIRT1, SKIL, ZNF165
Most correlated modules
- Early Response Stress · correlation 0.87
- AP-1 Immediate Early · correlation 0.86
- B cell quiescence · correlation 0.86
- ATF4 Stress Response · correlation 0.84
- NF-kB signaling · correlation 0.82
- Immediate Early NFkB · correlation 0.82
- mRNA Splicing · correlation 0.81
- Plasma cell secretory · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.