Immediate early response
Gene co-expression module in CD19⁺ B cells
| Category | BCR/AP1/NFKb pathway |
|---|---|
| Genes | 16 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes are dominated by immediate-early / circadian-responsive transcriptional regulators: PER1 (circadian), NR4A3 (orphan nuclear receptor, immediate-early), CREM, KDM4B, USP36, JMY, CCNT1. These are activity-dependent transcription factor responses typical of NFkB/AP1-driven immediate early signaling. Core coherence, uniform expression. Consistent with a transcriptional activation / immediate-early program.
Genes
CCNT1, CREM, HES4, JMY, JOSD1, KDM4B, NR4A3, PCNX4, PER1, PRNP, RALGAPA1, RLF, SERINC3, USP36, ZBTB21, ZDBF2
Most correlated modules
- Plasma cell secretory · correlation 0.93
- Hypoxia/metabolic stress · correlation 0.89
- NF-kB signaling · correlation 0.88
- NF-kB activation/survival · correlation 0.81
- B cell quiescence · correlation 0.77
- Notch signaling · correlation 0.76
- Integrated Stress Response · correlation 0.76
- Early Response Stress · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.