Early Response Stress
Gene co-expression module in CD19⁺ B cells
| Category | Stress |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
Mixed early-response and stress: DNAJA1 (HSP40), SOCS3, NR4A2, SAT1, UBC, UBB, ANKRD37 (hypoxia), SIK1. Combination of immediate-early (NR4A2, SIK1, SOCS3) and ubiquitin/chaperone stress. Neighbor of AP-1 (M44) and ISR modules; the early-response/stress character dominates with NR4A2 and SIK1 as activation markers.
Genes
ANKRD37, DNAJA1, GTF2B, NR4A2, SAT1, SIK1, SOCS3, UBB, UBC
Most correlated modules
- AP-1 Immediate Early · correlation 0.92
- Integrated Stress Response · correlation 0.87
- Immediate Early NFkB · correlation 0.85
- B cell quiescence · correlation 0.84
- Heat Shock Response · correlation 0.79
- Activation/Migration · correlation 0.77
- Plasma cell secretory · correlation 0.75
- Immediate early response · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.