PSMD14 — Proteasome 26S subunit, non-ATPase 14
PSMD14 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PSMD14's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Proteasome Complex Protein processing & ER | HPRT1, MRPL22, MRPS18C, PIN1, PSMB7, PSMD2, PSMD7, RAB8A +3 more | View in SCUBA |
| CD4⁺ T cells | Proteasome translation Housekeeping | ADRM1, CD2BP2, CDV3, CST7, EHBP1L1, EIF3J, ENO1, HSBP1 +5 more | View in SCUBA |
| CD8⁺ T cells | Proteostasis Translation Protein processing & ER | BZW1, CCT5, CCT7, EIF2S2, HNRNPC, HNRNPM, MDH1, PCBP1 +3 more | View in SCUBA |
| Gamma-delta T cells | T Cell Phosphatase Signaling TCR Signaling | AMZ2, ASTE1, DNAJB11, DR1, EFCAB2, IFIT3, PTPN7, SAR1A +4 more | |
| Goblet cells | Proteostasis Housekeeping Housekeeping | ADRM1, EIF2S2, GNB2, MAGOHB, NME1, NUDC, OAZ1, PARK7 +4 more | View in SCUBA |
| Innate lymphoid cells | RNA Processing & Proteostasis RNA processing & translation | BZW1, CBX5, CSNK1A1, DDX21, EIF2S1, EIF3J, ENPP1, FNBP1 +11 more | View in SCUBA |
| Macrophages | Mitochondrial Housekeeping Mitochondrial & OxPhos | BLOC1S2, BUD31, C14orf119, CCT5, CDC26, DGUOK, EIF2S1, GADD45GIP1 +11 more | View in SCUBA |
About the gene
| Synonyms | pad1, POH1, Rpn11 |
|---|---|
| Chromosome | 2: 161308425-161411717 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Enzymes, Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase, Metalloprotease, Protease |
| Biological process | DNA damage, DNA repair, Ubl conjugation pathway |
Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.