SCUBA

RNASEH2C — Ribonuclease H2 subunit C

RNASEH2C belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

RNASEH2C's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsProteasome Complex
Protein processing & ER
HPRT1, MRPL22, MRPS18C, PIN1, PSMB7, PSMD14, PSMD2, PSMD7 +3 moreView in SCUBA
CD8⁺ T cellsCellular Housekeeping
Housekeeping
ACAT2, ACOT7, CISD2, FDPS, NUDT21, PA2G4, PPIA, PSMC3 +9 moreView in SCUBA
EndothelialHousekeeping Metabolic
Housekeeping
ANXA5, ATP5MC3, CCT5, COX6B1, CTSL, DCTPP1, ERH, GSTO1 +8 moreView in SCUBA
Gamma-delta T cellsCellular Homeostasis
Housekeeping
ANAPC11, BANF1, CALM3, CBX3, CBX5, COMMD4, DPM2, DUT +21 more
Innate lymphoid cellsProteasome ER Proteostasis
Protein processing & ER
ATP5MC1, ATP5PF, DBI, GNG5, GTF3C6, HNRNPK, IL4I1, MANF +19 moreView in SCUBA
Lymphatic endothelialHousekeeping Mixed
Housekeeping
GUK1, LAMTOR4, NDUFB11, NEDD8, PRDX5, SSR4, VPS28, ZNHIT1View in SCUBA
Mucosal-associated invariant T cellCellular Housekeeping
Housekeeping
ABI3, AP2M1, CD151, CD2, CKLF, DYNLL1, FDFT1, LRP10 +7 more
Smooth muscle cellsER-Golgi Secretory
Protein processing & ER
ARL2, ATP2A2, BMP2, CD46, LAMB2, PLXND1, SPTB, YIF1AView in SCUBA

About the gene

SynonymsAGS3, AYP1
Chromosome11: 65714005-65720818
Predicted locationIntracellular
Essential geneNo
Protein classDisease related genes, Human disease related genes, Predicted intracellular proteins

Function

Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.