HPRT1 — Hypoxanthine phosphoribosyltransferase 1

HPRT1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

HPRT1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Proteasome Complex Protein processing & ER	MRPL22, MRPS18C, PIN1, PSMB7, PSMD14, PSMD2, PSMD7, RAB8A +3 more	View in SCUBA
CD4⁺ T cells	RNA processing splicing RNA processing	BUD31, DNAJC8, EDF1, EIF2S1, GTF3C6, ILF2, LAMTOR5, MIIP +11 more	View in SCUBA
CD8⁺ T cells	Histone Synthesis S-phase Cell cycle	CDK2, EIF4EBP1, HAT1, HNRNPF, PAQR4, RMI2, SLBP, TMEM109	View in SCUBA
Gamma-delta T cells	IRF4 T-cell Activation T cell maturation	APOA1, APOA4, CD59, FCER1G, FES, FUCA1, GEM, GRAMD2B +14 more
Innate lymphoid cells	Mixed Proteostasis Metabolism Metabolism	ADRM1, ANXA11, ATP6V0B, CISD2, COX17, DNAJC8, DR1, EIF3I +18 more	View in SCUBA
Macrophages	Mitotic Spindle Assembly Cell cycle	ACTL6A, AKR7A2, ANP32E, BOLA3, BUB3, CCDC167, CENPW, CENPX +34 more	View in SCUBA

About the gene

Synonyms	HGPRT, HPRT
Chromosome	X: 134460165-134520513
Predicted location	Intracellular
Essential gene	No
Protein class	Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Molecular function	Glycosyltransferase, Transferase
Biological process	Purine salvage

Function

Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.