SCUBA

SRSF9 — Serine and arginine rich splicing factor 9

SRSF9 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SRSF9's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsmRNA Splicing
RNA processing
CLTA, FKBP1A, HNRNPC, HNRNPK, RAC1, SLC25A3, SLC25A5, TKT +1 moreView in SCUBA
CD4⁺ T cellsMitochondrial OxPhos
Mitochondrial & OxPhos
AP2M1, ATP5MF, ATP6V0B, AURKAIP1, BSG, CALM3, CLTB, CSNK2B +19 moreView in SCUBA
CD8⁺ T cellsMitochondrial OxPhos
Mitochondrial & OxPhos
COX6B1, COX6C, COX7A2, COX7B, DBI, ELOB, LSM7, NDUFB2 +5 moreView in SCUBA
EndothelialmRNA Splicing Stress
RNA processing & translation
CCDC50, CCT6A, FAM114A1, GLRX3, PPM1G, RTRAF, TXNL4A, YWHAEView in SCUBA
FibroblastsGeneral Housekeeping
Housekeeping
ATP6V0E1, C19orf53, CLTA, EDF1, ERH, NEDD8, PARK7, SEC11A +4 moreView in SCUBA
Gamma-delta T cellsT-bet Effector Differentiation
T cell maturation
ABHD17A, BCL7C, CAPNS1, CHST12, DGKZ, EFHD2, FMNL1, GNAI2 +15 more
Goblet cellsSR Splicing Factors
RNA processing & translation
CLTA, GLRX5, MLEC, NDUFAB1, PPP1R14B, SRSF2, TRIR, UQCRFS1 +1 moreView in SCUBA
Innate lymphoid cellsInnate Immune Activation
Inflammation
ANKRD11, ATP10D, CNOT2, COA4, DOCK10, IKZF2, NIFK, PRKDC +13 moreView in SCUBA
MacrophagesProteasome UPS
Housekeeping
ACP1, ARPC5L, ATP6V1G1, AURKAIP1, C19orf53, CHMP2A, CIAO2B, CIB1 +31 moreView in SCUBA

About the gene

SynonymsSFRS9, SRp30c
Chromosome12: 120461672-120495946
Predicted locationIntracellular
Essential geneNo
Protein classPredicted intracellular proteins
Molecular functionRepressor, RNA-binding
Biological processmRNA processing, mRNA splicing

Function

Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.