HNRNPK — Heterogeneous nuclear ribonucleoprotein K
HNRNPK belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HNRNPK's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | mRNA Splicing RNA processing | CLTA, FKBP1A, HNRNPC, RAC1, SLC25A3, SLC25A5, SRSF9, TKT +1 more | View in SCUBA |
| Fibroblasts | ER Protein Folding Housekeeping | AHCYL1, CANX, CSNK1A1, HSP90B1, JAK1, KDELR1, KTN1, LAMTOR1 +10 more | View in SCUBA |
| Gamma-delta T cells | Interferon Stimulated Genes Inflammation | AATF, ACSL5, ACTR10, AGL, DDX60, DTX3L, HCLS1, HIF1AN +14 more | |
| Innate lymphoid cells | Proteasome ER Proteostasis Protein processing & ER | ATP5MC1, ATP5PF, DBI, GNG5, GTF3C6, IL4I1, MANF, MED10 +19 more | View in SCUBA |
| Macrophages | Actin Cytoskeleton Organization Cytoskeletal | ACTR3, ARF1, ARHGDIA, ARPC4, CDC42, DERL1, EIF4G2, GARS1 +20 more | View in SCUBA |
| Pericytes | mRNA Stability Regulation Housekeeping | ACTR2, EIF4G2, MTDH, MTPN, QKI, SERBP1, SET | View in SCUBA |
About the gene
| Synonyms | CSBP, HNRPK, TUNP |
|---|---|
| Chromosome | 9: 83968083-83980631 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Activator, DNA-binding, Repressor, Ribonucleoprotein, RNA-binding |
| Biological process | Host-virus interaction, mRNA processing, mRNA splicing, Transcription, Transcription regulation |
Function
One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.