Dark-zone GC B-cell
Gene co-expression module in CD19⁺ B cells
| Category | B cell maturation |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 11 genes have a known function matching the annotation |
Why this annotation
Very low expression (6% positive) but core coherence. Strong dark-zone / proliferating germinal center B-cell / plasmablast precursor signature: CD38 (GC/plasmablast marker), MYBL1 (GC B-cell transcription factor), BRWD1 (chromatin reader essential for B-cell development/light-chain recombination), CCDC88A/girdin and migration genes LPP, MYO1E, SYNE2, FGD6, RAPGEF5. Combination of CD38, MYBL1, BRWD1 strongly indicates germinal center dark-zone B-cell state. Uniform among B cells; not contamination.
Genes
BRWD1, CCDC144A, CCDC88A, CD38, FGD6, LPP, MYBL1, MYO1E, RAPGEF5, SYNE2, ZNF608
Most correlated modules
- Germinal center B-cell · correlation 0.94
- Somatic Hypermutation · correlation 0.94
- Germinal Center Maturation · correlation 0.89
- B-cell activation signaling · correlation 0.85
- Naive B-cell identity · correlation 0.80
- B-cell signaling regulators · correlation 0.80
- Actin cytoskeleton remodeling · correlation 0.76
- MHC-II antigen presentation · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.