Cytoskeleton/motility
Gene co-expression module in CD19⁺ B cells
| Category | migration & adhesion |
|---|---|
| Genes | 20 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 20 genes have a known function matching the annotation |
Why this annotation
Dominated by S100 proteins (S100A11, S100A4, S100A6), VIM, LGALS1, ANXA2, ANXA4, MSN, CAPG, LSP1 — a cytoskeletal/motility and calcium-binding signature characteristic of migratory effector/atypical B cells. PYCARD adds inflammasome. This reflects a migration/cytoskeletal remodeling program seen in activated tissue B cells.
Genes
ANXA2, ANXA4, BHLHE41, C4orf48, CAPG, CAPN2, CIB1, ISCU, LGALS1, LSP1, MSN, PTMS, PYCARD, S100A11, S100A4, S100A6, SELENOW, SUB1, TESC, VIM
Most correlated modules
- Activated B cell · correlation 0.81
- Tissue-resident memory B · correlation 0.75
- Lysosomal proteases · correlation 0.71
- Actin Cytoskeleton · correlation 0.70
- B cell activation · correlation 0.63
- Atypical memory B cell · correlation 0.63
- ER/vesicle trafficking · correlation 0.61
- Membrane adhesion remodeling · correlation 0.61
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.