Membrane adhesion remodeling
Gene co-expression module in CD19⁺ B cells
| Category | migration & adhesion |
|---|---|
| Genes | 15 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes are a mix of membrane/cytoskeletal and signaling genes (ARL6IP5, EMP3, FXYD5, FLNA, PLP2, SUN2) with some immune/TNF family signaling (TNFSF12/TWEAK, IL27RA, LY96/MD2, CAST, CAMK1D). The strongest coherent theme is membrane-associated proteins and cytoskeletal/adhesion regulators (EMP3, FXYD5, FLNA, PLP2, SUN2). FXYD5 and EMP3 are markers of cell membrane remodeling and migration/adhesion. Uniform low-level expression across subsets. The module is heterogeneous but leans toward membrane/cytoskeletal-adhesion biology rather than a single canonical B cell program.
Genes
ARL6IP5, ATP6V0E1, CAMK1D, CAST, CELF2, DDAH2, EMP3, FLNA, FXYD5, IL27RA, LY96, PKIG, PLP2, SUN2, TNFSF12
Most correlated modules
- MHC-I Antigen Presentation · correlation 0.85
- Interferon Response · correlation 0.79
- B cell activation signaling · correlation 0.78
- TNF/NF-kB response · correlation 0.77
- MHC-II antigen presentation · correlation 0.75
- Lysosomal proteases · correlation 0.71
- Activated B cell · correlation 0.70
- Tissue-resident memory B · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.