Tissue-resident memory B
Gene co-expression module in CD19⁺ B cells
| Category | B cell maturation |
|---|---|
| Genes | 13 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 13 genes have a known function matching the annotation |
Why this annotation
FCRL4 and CCR1 define tissue-resident/mucosa-associated memory B cells (FCRL4+ B cells found in gut epithelium). ITGB7 (gut homing integrin), VSIR (VISTA, inhibitory checkpoint), RUNX2, SEMA4D support a mucosal tissue-resident atypical memory B-cell state. PLD4, PIK3R6 signaling. Coherent gut-resident memory B cell program.
Genes
CALHM2, CCR1, CMTM7, FCRL4, FGD4, GSN, ITGB7, PIK3R6, PLD4, PSAP, RUNX2, SEMA4D, VSIR
Most correlated modules
- Activated B cell · correlation 0.88
- Lysosomal proteases · correlation 0.86
- Atypical memory B cell · correlation 0.84
- Cytoskeleton/motility · correlation 0.75
- B cell activation · correlation 0.74
- ER/vesicle trafficking · correlation 0.73
- B-cell activation · correlation 0.73
- B cell activation · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.