ER/vesicle trafficking
Gene co-expression module in CD19⁺ B cells
| Category | Protein processing & ER |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes REEP5, M6PR, ATP6V0B, TMBIM6, SCPEP1 are involved in ER/endolysosomal trafficking and vesicular transport, broadly expressed housekeeping-type genes (CD99, HCST also present). Uniform expression, high detection rate, no specific B cell program. Represents general secretory/membrane housekeeping machinery.
Genes
ATP6V0B, CD99, DIAPH1, HCST, M6PR, MTDH, MTPN, REEP5, SCPEP1, TMBIM6
Most correlated modules
- B cell activation · correlation 0.87
- B-cell activation · correlation 0.81
- BCR Ras signaling · correlation 0.79
- Lysosomal proteases · correlation 0.78
- Activated B cell · correlation 0.75
- Atypical memory B cell · correlation 0.73
- Tissue-resident memory B · correlation 0.73
- B Cell Identity Signaling · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.