ER protein processing
Gene co-expression module in CD4⁺ T cells
| Category | Protein processing & ER |
|---|---|
| Genes | 8 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes are ER and protein processing/secretory machinery: PDIA6 (protein disulfide isomerase), SPCS2 (signal peptidase), SDF2L1 (ER chaperone, UPR), KDELR2 (ER retrieval receptor), plus proteasome (PSMC3/PSMC4, UBE2L3 ubiquitin conjugation) and EIF6 (ribosome biogenesis). This is a coherent ER/protein processing and degradation (UPR-related proteostasis) module.
Genes
EIF6, KDELR2, PDIA6, PSMC3, PSMC4, SDF2L1, SPCS2, UBE2L3
Most correlated modules
- Proteasome translation · correlation 0.92
- Mitochondrial OxPhos · correlation 0.92
- Interferon-stimulated genes · correlation 0.90
- Proteostasis OxPhos · correlation 0.84
- Nucleotide biosynthesis · correlation 0.84
- Actin cytoskeleton · correlation 0.83
- RNA processing splicing · correlation 0.81
- Oxidative Phosphorylation · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.