Actin cytoskeleton
Gene co-expression module in CD4⁺ T cells
| Category | Cytoskeletal |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes are actin cytoskeleton/Arp2/3 complex (ARPC3, ARPC2, BRK1-like), PFN1, ACTB, ACTG1, RHOA, plus glycolytic housekeeping (GAPDH). This is clearly an actin cytoskeleton/cell motility module. High expression and detection, uniform. Cytoskeletal program.
Genes
ACTB, ACTG1, ARPC2, ARPC3, CLIC1, COPE, ELOB, GAPDH, PFN1, PPP1CA, RHOA, SERF2
Most correlated modules
- Cytoskeleton & metabolism · correlation 0.91
- Interferon-stimulated genes · correlation 0.89
- Proteostasis OxPhos · correlation 0.88
- Mitochondrial OxPhos · correlation 0.86
- OxPhos & proteasome · correlation 0.86
- OxPhos & redox · correlation 0.84
- TCR Complex Activation · correlation 0.84
- Interferon response · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.