SPCS2 — Signal peptidase complex subunit 2
SPCS2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SPCS2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | ER protein processing Protein processing & ER | EIF6, KDELR2, PDIA6, PSMC3, PSMC4, SDF2L1, UBE2L3 | View in SCUBA |
| Fibroblasts | General Housekeeping Housekeeping | ATP6V0E1, C19orf53, CLTA, EDF1, ERH, NEDD8, PARK7, SEC11A +4 more | View in SCUBA |
| Goblet cells | ER Protein Translocation Protein processing & ER | DNAJC3, LMAN1, PDIA6, RPN2, SPCS3, SSR1, TMED10, TMED2 | View in SCUBA |
| Innate lymphoid cells | Proteasome ER Proteostasis Protein processing & ER | ATP5MC1, ATP5PF, DBI, GNG5, GTF3C6, HNRNPK, IL4I1, MANF +19 more | View in SCUBA |
| Macrophages | ER Protein Processing Housekeeping | ACTR1A, ANXA7, ATP6AP1, ATP6AP2, ATP6V0B, ATP6V0E1, AUP1, BCAP31 +41 more | View in SCUBA |
| Smooth muscle cells | Mitochondrial Housekeeping Housekeeping | APP, COX7A2L, EIF5B, GABARAPL2, LAMTOR4, NDUFAB1, PGAM1, TMEM14C +2 more | View in SCUBA |
About the gene
| Synonyms | KIAA0102 |
|---|---|
| Chromosome | 11: 74949261-74979033 |
| Predicted location | Intracellular, Membrane |
| Essential gene | Yes |
| Protein class | Essential proteins, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
Function
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.