ZBTB1 — Zinc finger and BTB domain containing 1
ZBTB1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ZBTB1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | NF-kB signaling BCR/AP1/NFKb pathway | ARIH1, BACH1, BRAF, HERPUD1, MTMR6, RAB21, RASGEF1B, REL +5 more | View in SCUBA |
| CD4⁺ T cells | T-cell quiescence regulation Immune regulation | CDC42SE2, CDKN1B, FOXP1, ICAM2, KRAS, MRPS6, MSL3, SERINC5 +4 more | View in SCUBA |
| Gamma-delta T cells | Late Activation Autophagy Immune regulation | BCL3, BRD1, CREM, DUSP8, FAM177A1, FBXO33, FOSL2, GABARAPL1 +19 more | |
| Innate lymphoid cells | Prostaglandin-AP1 Response Inflammation | ARIH1, ARL5B, CCNT1, CHD1, CXCL2, ETV3, FOSL2, IRF2BP2 +12 more | View in SCUBA |
| Macrophages | NF-κB Activation Inflammatory | BCL3, BLOC1S6, CD83, CFLAR, CHMP1B, CNOT2, CSRNP1, CYLD +33 more | View in SCUBA |
| Mucosal-associated invariant T cell | RUNX3 Tissue Identity T cell maturation | B4GALT1, CD44, CDK17, CHD1, CYLD, EML4, EP300, GPBP1 +10 more | |
| Natural Killer cells | TGF-β Antagonism Immune regulation | IFRD1, IRS2, MOB3A, RBM39, SBDS, SMAD7, SRSF5, STK17B +1 more | View in SCUBA |
About the gene
| Synonyms | KIAA0997, ZNF909 |
|---|---|
| Chromosome | 14: 64503712-64533690 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | DNA-binding, Repressor |
| Biological process | Differentiation, DNA damage, DNA repair, Immunity, Innate immunity, Transcription, Transcription regulation |
Function
Acts as a transcriptional repressor. Represses cAMP-responsive element (CRE)-mediated transcriptional activation. In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis. Plays a key role in the transcriptional regulation of T lymphocyte development (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.