KRAS — KRAS proto-oncogene, GTPase
KRAS belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KRAS's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | T-cell quiescence regulation Immune regulation | CDC42SE2, CDKN1B, FOXP1, ICAM2, MRPS6, MSL3, SERINC5, SLC5A3 +4 more | View in SCUBA |
| Endothelial | Inflammatory Stress Response Stress | CRK, DLC1, GCLM, IFT20, ODC1, SBDS, SERP1, SERPINH1 +7 more | View in SCUBA |
| Innate lymphoid cells | ER-Golgi Trafficking Protein processing & ER | ATP2B1, ATP6V1D, CAPZA2, CGGBP1, CNOT4, COPS5, CRIPT, CSTB +15 more | View in SCUBA |
| Macrophages | RAS-MAPK Signaling Housekeeping | ARF4, ATG12, CAMTA1, CDC37, CHMP4B, ETFA, GLA, HMGA1 +26 more | View in SCUBA |
| Pericytes | RAS Cytoskeletal Signaling Cytoskeletal | ARPC5L, CNDP2, FAM177A1, KLF3, LRRFIP1, PEA15, PTPN12, UBE2J1 | View in SCUBA |
About the gene
| Synonyms | K-Ras4B, KRAS1, KRAS2 |
|---|---|
| Chromosome | 12: 25205246-25250936 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, RAS pathway related proteins |
| Molecular function | Hydrolase |
Function
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.