mRNA Processing
Gene co-expression module in CD4⁺ T cells
| Category | RNA processing |
|---|---|
| Genes | 18 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 18 genes have a known function matching the annotation |
Why this annotation
Mixed module with RNA processing/splicing hubs: SNRPB2 (U2 snRNP), STAU1 (Staufen RNA binding), LSM1 (mRNA decapping/decay), HNRNPL (hnRNP splicing), SINHCAF, CCND3 (cyclin), PSMA3 (proteasome), DBF4 (DNA replication licensing). Strong RNA-binding/processing theme among membership-strong genes. Moderate coherence indicates mixed program but RNA processing dominates the coherent core.
Genes
ABI1, AGFG1, CCND3, CD164, CHMP2B, DBF4, GHITM, HNRNPL, LSM1, MAFG, PDCD10, PSMA3, RALBP1, SINHCAF, SNRPB2, STAU1, TLE3, TMEM256
Most correlated modules
- Membrane Trafficking · correlation 0.94
- Oxidative Phosphorylation · correlation 0.85
- Lipid Metabolism · correlation 0.85
- Mitochondrial Translation · correlation 0.84
- T-cell quiescence regulation · correlation 0.82
- CD4 Lineage Identity · correlation 0.81
- T Cell Signaling · correlation 0.81
- Vesicle Trafficking Signaling · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.